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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C18H20N2O6
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
H. Meyar et al., Ger. pat 2117571; eidem, US pat. 3799934
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Molecular Weight
360.361 g/mol
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Melting Point
156-160 oC
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H2O Solubility
Insoluble
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State
Solid
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LogP
2.756
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Dosage Forms
No information avaliable
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Indication
For the treatment of mild to moderate hypertension
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Pharmacology
Nitrendipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nitrendipine is similar to other peripheral vasodilators. Nitrendipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
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Absorption
No information avaliable
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side effects and Toxicity
No information avaliable
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals