Nitrendipine, Pharma
Nitrendipine, Pharma Brand names, Nitrendipine, Pharma Analogs
Nitrendipine, Pharma Brand Names Mixture
- No information avaliable
Nitrendipine, Pharma Chemical_Formula
C18H20N2O6
Nitrendipine, Pharma RX_link
No information avaliable
Nitrendipine, Pharma fda sheet
Nitrendipine, Pharma msds (material safety sheet)
Nitrendipine, Pharma Synthesis Reference
H. Meyar et al., Ger. pat 2117571; eidem, US pat. 3799934
Nitrendipine, Pharma Molecular Weight
360.361 g/mol
Nitrendipine, Pharma Melting Point
156-160 oC
Nitrendipine, Pharma H2O Solubility
Insoluble
Nitrendipine, Pharma State
Solid
Nitrendipine, Pharma LogP
2.756
Nitrendipine, Pharma Dosage Forms
No information avaliable
Nitrendipine, Pharma Indication
For the treatment of mild to moderate hypertension
Nitrendipine, Pharma Pharmacology
Nitrendipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nitrendipine is similar to other peripheral vasodilators. Nitrendipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Nitrendipine, Pharma Absorption
No information avaliable
Nitrendipine, Pharma side effects and Toxicity
No information avaliable
Nitrendipine, Pharma Patient Information
No information avaliable
Nitrendipine, Pharma Organisms Affected
Humans and other mammals
