Nitrendipin
Nitrendipin Brand names, Nitrendipin Analogs
Nitrendipin Brand Names Mixture
- No information avaliable
Nitrendipin Chemical_Formula
C18H20N2O6
Nitrendipin RX_link
No information avaliable
Nitrendipin fda sheet
Nitrendipin msds (material safety sheet)
Nitrendipin Synthesis Reference
H. Meyar et al., Ger. pat 2117571; eidem, US pat. 3799934
Nitrendipin Molecular Weight
360.361 g/mol
Nitrendipin Melting Point
156-160 oC
Nitrendipin H2O Solubility
Insoluble
Nitrendipin State
Solid
Nitrendipin LogP
2.756
Nitrendipin Dosage Forms
No information avaliable
Nitrendipin Indication
For the treatment of mild to moderate hypertension
Nitrendipin Pharmacology
Nitrendipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nitrendipine is similar to other peripheral vasodilators. Nitrendipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Nitrendipin Absorption
No information avaliable
Nitrendipin side effects and Toxicity
No information avaliable
Nitrendipin Patient Information
No information avaliable
Nitrendipin Organisms Affected
Humans and other mammals
