Nidrel
Nidrel Brand names, Nidrel Analogs
Nidrel Brand Names Mixture
- No information avaliable
Nidrel Chemical_Formula
C18H20N2O6
Nidrel RX_link
No information avaliable
Nidrel fda sheet
Nidrel msds (material safety sheet)
Nidrel Synthesis Reference
H. Meyar et al., Ger. pat 2117571; eidem, US pat. 3799934
Nidrel Molecular Weight
360.361 g/mol
Nidrel Melting Point
156-160 oC
Nidrel H2O Solubility
Insoluble
Nidrel State
Solid
Nidrel LogP
2.756
Nidrel Dosage Forms
No information avaliable
Nidrel Indication
For the treatment of mild to moderate hypertension
Nidrel Pharmacology
Nitrendipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nitrendipine is similar to other peripheral vasodilators. Nitrendipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Nidrel Absorption
No information avaliable
Nidrel side effects and Toxicity
No information avaliable
Nidrel Patient Information
No information avaliable
Nidrel Organisms Affected
Humans and other mammals
