Monistat Dual- PAK
Brand names,
Monistat Dual- PAK
Analogs
Monistat Dual- PAK
Brand Names Mixture
Monistat Dual- PAK
Chemical_Formula
C27H34N2O7
Monistat Dual- PAK
RX_link
http://www.rxlist.com/cgi/generic2/moexip.htm
Monistat Dual- PAK
fda sheet
Monistat Dual- PAK
msds (material safety sheet)
Monistat Dual- PAK
Synthesis Reference
No information avaliable
Monistat Dual- PAK
Molecular Weight
498.568 g/mol
Monistat Dual- PAK
Melting Point
No information avaliable
Monistat Dual- PAK
H2O Solubility
Soluble (about 10% weight-to-volume) in distilled water at room temperature as HCl salt.
Monistat Dual- PAK
State
Solid
Monistat Dual- PAK
LogP
3.31
Monistat Dual- PAK
Dosage Forms
Tablets (scored, coated, containing 7.5 mg or 15 mg of moexipril hydrochloride for oral administration)
Monistat Dual- PAK
Indication
For treatment of patients with hypertension.
Monistat Dual- PAK
Pharmacology
Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.
Monistat Dual- PAK
Absorption
Moexipril is incompletely absorbed, with bioavailability as moexiprilat of about 13% compared to intravenous (I.V.) moexipril (both measuring the metabolite moexiprilat), and is markedly affected by food, which reduces Cmax and AUC by about 70% and 40% respectively after the ingestion of a low-fat breakfast or by 80% and 50% respectively after the ingestion of a high-fat breakfast.
Monistat Dual- PAK
side effects and Toxicity
Human overdoses of moexipril have not been reported. In case reports of overdoses with other ACE inhibitors, hypotension has been the principal adverse effect noted. Single oral doses of 2 g/kg moexipril were associated with significant lethality in mice. Rats, however, tolerated single oral doses of up to 3 g/kg.
Monistat Dual- PAK
Patient Information
Monistat Dual- PAK
Organisms Affected
Humans and other mammals