Zeasorb-AF

Zeasorb-AF Brand names, Zeasorb-AF Analogs

Zeasorb-AF Brand Names Mixture

No information avaliable

Zeasorb-AF Chemical_Formula

C₂₇H₃₄N₂O₇

Zeasorb-AF RX_link

http://www.rxlist.com/cgi/generic2/moexip.htm

Zeasorb-AF fda sheet

Zeasorb-AF msds (material safety sheet)

Zeasorb-AF Synthesis Reference

No information avaliable

Zeasorb-AF Molecular Weight

498.568 g/mol

Zeasorb-AF Melting Point

No information avaliable

Zeasorb-AF H₂O Solubility

Soluble (about 10% weight-to-volume) in distilled water at room temperature as HCl salt.

Zeasorb-AF State

Solid

Zeasorb-AF LogP

3.31

Zeasorb-AF Dosage Forms

Tablets (scored, coated, containing 7.5 mg or 15 mg of moexipril hydrochloride for oral administration)

Zeasorb-AF Indication

For treatment of patients with hypertension.

Zeasorb-AF Pharmacology

Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.

Zeasorb-AF Absorption

Moexipril is incompletely absorbed, with bioavailability as moexiprilat of about 13% compared to intravenous (I.V.) moexipril (both measuring the metabolite moexiprilat), and is markedly affected by food, which reduces C_max and AUC by about 70% and 40% respectively after the ingestion of a low-fat breakfast or by 80% and 50% respectively after the ingestion of a high-fat breakfast.

Zeasorb-AF side effects and Toxicity

Human overdoses of moexipril have not been reported. In case reports of overdoses with other ACE inhibitors, hypotension has been the principal adverse effect noted. Single oral doses of 2 g/kg moexipril were associated with significant lethality in mice. Rats, however, tolerated single oral doses of up to 3 g/kg.

Zeasorb-AF Patient Information

Zeasorb-AF Organisms Affected

Humans and other mammals