Miconazole Nitrate
Brand names,
Miconazole Nitrate
Analogs
Miconazole Nitrate
Brand Names Mixture
Miconazole Nitrate
Chemical_Formula
C27H34N2O7
Miconazole Nitrate
RX_link
http://www.rxlist.com/cgi/generic2/moexip.htm
Miconazole Nitrate
fda sheet
Miconazole Nitrate
msds (material safety sheet)
Miconazole Nitrate
Synthesis Reference
No information avaliable
Miconazole Nitrate
Molecular Weight
498.568 g/mol
Miconazole Nitrate
Melting Point
No information avaliable
Miconazole Nitrate
H2O Solubility
Soluble (about 10% weight-to-volume) in distilled water at room temperature as HCl salt.
Miconazole Nitrate
State
Solid
Miconazole Nitrate
LogP
3.31
Miconazole Nitrate
Dosage Forms
Tablets (scored, coated, containing 7.5 mg or 15 mg of moexipril hydrochloride for oral administration)
Miconazole Nitrate
Indication
For treatment of patients with hypertension.
Miconazole Nitrate
Pharmacology
Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.
Miconazole Nitrate
Absorption
Moexipril is incompletely absorbed, with bioavailability as moexiprilat of about 13% compared to intravenous (I.V.) moexipril (both measuring the metabolite moexiprilat), and is markedly affected by food, which reduces Cmax and AUC by about 70% and 40% respectively after the ingestion of a low-fat breakfast or by 80% and 50% respectively after the ingestion of a high-fat breakfast.
Miconazole Nitrate
side effects and Toxicity
Human overdoses of moexipril have not been reported. In case reports of overdoses with other ACE inhibitors, hypotension has been the principal adverse effect noted. Single oral doses of 2 g/kg moexipril were associated with significant lethality in mice. Rats, however, tolerated single oral doses of up to 3 g/kg.
Miconazole Nitrate
Patient Information
Miconazole Nitrate
Organisms Affected
Humans and other mammals