Monistat 3 Dual-Pak
Brand names,
Monistat 3 Dual-Pak
Analogs
Monistat 3 Dual-Pak
Brand Names Mixture
Monistat 3 Dual-Pak
Chemical_Formula
C27H34N2O7
Monistat 3 Dual-Pak
RX_link
http://www.rxlist.com/cgi/generic2/moexip.htm
Monistat 3 Dual-Pak
fda sheet
Monistat 3 Dual-Pak
msds (material safety sheet)
Monistat 3 Dual-Pak
Synthesis Reference
No information avaliable
Monistat 3 Dual-Pak
Molecular Weight
498.568 g/mol
Monistat 3 Dual-Pak
Melting Point
No information avaliable
Monistat 3 Dual-Pak
H2O Solubility
Soluble (about 10% weight-to-volume) in distilled water at room temperature as HCl salt.
Monistat 3 Dual-Pak
State
Solid
Monistat 3 Dual-Pak
LogP
3.31
Monistat 3 Dual-Pak
Dosage Forms
Tablets (scored, coated, containing 7.5 mg or 15 mg of moexipril hydrochloride for oral administration)
Monistat 3 Dual-Pak
Indication
For treatment of patients with hypertension.
Monistat 3 Dual-Pak
Pharmacology
Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.
Monistat 3 Dual-Pak
Absorption
Moexipril is incompletely absorbed, with bioavailability as moexiprilat of about 13% compared to intravenous (I.V.) moexipril (both measuring the metabolite moexiprilat), and is markedly affected by food, which reduces Cmax and AUC by about 70% and 40% respectively after the ingestion of a low-fat breakfast or by 80% and 50% respectively after the ingestion of a high-fat breakfast.
Monistat 3 Dual-Pak
side effects and Toxicity
Human overdoses of moexipril have not been reported. In case reports of overdoses with other ACE inhibitors, hypotension has been the principal adverse effect noted. Single oral doses of 2 g/kg moexipril were associated with significant lethality in mice. Rats, however, tolerated single oral doses of up to 3 g/kg.
Monistat 3 Dual-Pak
Patient Information
Monistat 3 Dual-Pak
Organisms Affected
Humans and other mammals