Miconazole 3
Brand names,
Miconazole 3
Analogs
Miconazole 3
Brand Names Mixture
Miconazole 3
Chemical_Formula
C27H34N2O7
Miconazole 3
RX_link
http://www.rxlist.com/cgi/generic2/moexip.htm
Miconazole 3
fda sheet
Miconazole 3
msds (material safety sheet)
Miconazole 3
Synthesis Reference
No information avaliable
Miconazole 3
Molecular Weight
498.568 g/mol
Miconazole 3
Melting Point
No information avaliable
Miconazole 3
H2O Solubility
Soluble (about 10% weight-to-volume) in distilled water at room temperature as HCl salt.
Miconazole 3
State
Solid
Miconazole 3
LogP
3.31
Miconazole 3
Dosage Forms
Tablets (scored, coated, containing 7.5 mg or 15 mg of moexipril hydrochloride for oral administration)
Miconazole 3
Indication
For treatment of patients with hypertension.
Miconazole 3
Pharmacology
Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.
Miconazole 3
Absorption
Moexipril is incompletely absorbed, with bioavailability as moexiprilat of about 13% compared to intravenous (I.V.) moexipril (both measuring the metabolite moexiprilat), and is markedly affected by food, which reduces Cmax and AUC by about 70% and 40% respectively after the ingestion of a low-fat breakfast or by 80% and 50% respectively after the ingestion of a high-fat breakfast.
Miconazole 3
side effects and Toxicity
Human overdoses of moexipril have not been reported. In case reports of overdoses with other ACE inhibitors, hypotension has been the principal adverse effect noted. Single oral doses of 2 g/kg moexipril were associated with significant lethality in mice. Rats, however, tolerated single oral doses of up to 3 g/kg.
Miconazole 3
Patient Information
Miconazole 3
Organisms Affected
Humans and other mammals