M-zole 7 Dual Pack
Brand names,
M-zole 7 Dual Pack
Analogs
M-zole 7 Dual Pack
Brand Names Mixture
M-zole 7 Dual Pack
Chemical_Formula
C27H34N2O7
M-zole 7 Dual Pack
RX_link
http://www.rxlist.com/cgi/generic2/moexip.htm
M-zole 7 Dual Pack
fda sheet
M-zole 7 Dual Pack
msds (material safety sheet)
M-zole 7 Dual Pack
Synthesis Reference
No information avaliable
M-zole 7 Dual Pack
Molecular Weight
498.568 g/mol
M-zole 7 Dual Pack
Melting Point
No information avaliable
M-zole 7 Dual Pack
H2O Solubility
Soluble (about 10% weight-to-volume) in distilled water at room temperature as HCl salt.
M-zole 7 Dual Pack
State
Solid
M-zole 7 Dual Pack
LogP
3.31
M-zole 7 Dual Pack
Dosage Forms
Tablets (scored, coated, containing 7.5 mg or 15 mg of moexipril hydrochloride for oral administration)
M-zole 7 Dual Pack
Indication
For treatment of patients with hypertension.
M-zole 7 Dual Pack
Pharmacology
Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.
M-zole 7 Dual Pack
Absorption
Moexipril is incompletely absorbed, with bioavailability as moexiprilat of about 13% compared to intravenous (I.V.) moexipril (both measuring the metabolite moexiprilat), and is markedly affected by food, which reduces Cmax and AUC by about 70% and 40% respectively after the ingestion of a low-fat breakfast or by 80% and 50% respectively after the ingestion of a high-fat breakfast.
M-zole 7 Dual Pack
side effects and Toxicity
Human overdoses of moexipril have not been reported. In case reports of overdoses with other ACE inhibitors, hypotension has been the principal adverse effect noted. Single oral doses of 2 g/kg moexipril were associated with significant lethality in mice. Rats, however, tolerated single oral doses of up to 3 g/kg.
M-zole 7 Dual Pack
Patient Information
M-zole 7 Dual Pack
Organisms Affected
Humans and other mammals