Monistat 7 Vaginal Suppositories
Brand names,
Monistat 7 Vaginal Suppositories
Analogs
Monistat 7 Vaginal Suppositories
Brand Names Mixture
Monistat 7 Vaginal Suppositories
Chemical_Formula
C27H34N2O7
Monistat 7 Vaginal Suppositories
RX_link
http://www.rxlist.com/cgi/generic2/moexip.htm
Monistat 7 Vaginal Suppositories
fda sheet
Monistat 7 Vaginal Suppositories
msds (material safety sheet)
Monistat 7 Vaginal Suppositories
Synthesis Reference
No information avaliable
Monistat 7 Vaginal Suppositories
Molecular Weight
498.568 g/mol
Monistat 7 Vaginal Suppositories
Melting Point
No information avaliable
Monistat 7 Vaginal Suppositories
H2O Solubility
Soluble (about 10% weight-to-volume) in distilled water at room temperature as HCl salt.
Monistat 7 Vaginal Suppositories
State
Solid
Monistat 7 Vaginal Suppositories
LogP
3.31
Monistat 7 Vaginal Suppositories
Dosage Forms
Tablets (scored, coated, containing 7.5 mg or 15 mg of moexipril hydrochloride for oral administration)
Monistat 7 Vaginal Suppositories
Indication
For treatment of patients with hypertension.
Monistat 7 Vaginal Suppositories
Pharmacology
Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.
Monistat 7 Vaginal Suppositories
Absorption
Moexipril is incompletely absorbed, with bioavailability as moexiprilat of about 13% compared to intravenous (I.V.) moexipril (both measuring the metabolite moexiprilat), and is markedly affected by food, which reduces Cmax and AUC by about 70% and 40% respectively after the ingestion of a low-fat breakfast or by 80% and 50% respectively after the ingestion of a high-fat breakfast.
Monistat 7 Vaginal Suppositories
side effects and Toxicity
Human overdoses of moexipril have not been reported. In case reports of overdoses with other ACE inhibitors, hypotension has been the principal adverse effect noted. Single oral doses of 2 g/kg moexipril were associated with significant lethality in mice. Rats, however, tolerated single oral doses of up to 3 g/kg.
Monistat 7 Vaginal Suppositories
Patient Information
Monistat 7 Vaginal Suppositories
Organisms Affected
Humans and other mammals