Metolazone

Metolazone Brand names, Metolazone Analogs

Metolazone Brand Names Mixture

No information avaliable

Metolazone Chemical_Formula

C₁₆H₁₆ClN₃O₃S

Metolazone RX_link

http://www.rxlist.com/cgi/generic2/metolazone.htm

Metolazone fda sheet

Metolazone FDA

Metolazone msds (material safety sheet)

Metolazone Synthesis Reference

No information avaliable

Metolazone Molecular Weight

365.835 g/mol

Metolazone Melting Point

256 ^oC

Metolazone H₂O Solubility

60.3 mg/L

Metolazone State

Solid

Metolazone LogP

2.784

Metolazone Dosage Forms

Tablet for oral administration (0.5mg)

Metolazone Indication

For the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class.

Metolazone Pharmacology

Metolazone is a quinazoline diuretic, with properties generally similar to the thiazide diuretics. A proximal action of metolazone has been shown in humans by increased excretion of phosphate and magnesium ions and by a markedly increased fractional excretion of sodium in patients with severely compromised glomerular filtration. This action has been demonstrated in animals by micropuncture studies.

Metolazone Absorption

Peak blood levels are obtained within 2 to 4 hours of oral administration.

Metolazone side effects and Toxicity

Symptoms of overdose include difficulty breathing, dizziness, dizziness on standing up, drowsiness, fainting, irritation of the stomach and intestines, and lethargy leading to coma.

Metolazone Patient Information