Methixen [German]

Methixen [German] Brand names, Methixen [German] Analogs

Methixen [German] Brand Names Mixture

No information avaliable

Methixen [German] Chemical_Formula

C₁₆H₁₆ClN₃O₃S

Methixen [German] RX_link

http://www.rxlist.com/cgi/generic2/metolazone.htm

Methixen [German] fda sheet

Methixen_[German] FDA

Methixen [German] msds (material safety sheet)

Methixen [German] Synthesis Reference

No information avaliable

Methixen [German] Molecular Weight

365.835 g/mol

Methixen [German] Melting Point

256 ^oC

Methixen [German] H₂O Solubility

60.3 mg/L

Methixen [German] State

Solid

Methixen [German] LogP

2.784

Methixen [German] Dosage Forms

Tablet for oral administration (0.5mg)

Methixen [German] Indication

For the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class.

Methixen [German] Pharmacology

Metolazone is a quinazoline diuretic, with properties generally similar to the thiazide diuretics. A proximal action of metolazone has been shown in humans by increased excretion of phosphate and magnesium ions and by a markedly increased fractional excretion of sodium in patients with severely compromised glomerular filtration. This action has been demonstrated in animals by micropuncture studies.

Methixen [German] Absorption

Peak blood levels are obtained within 2 to 4 hours of oral administration.

Methixen [German] side effects and Toxicity

Symptoms of overdose include difficulty breathing, dizziness, dizziness on standing up, drowsiness, fainting, irritation of the stomach and intestines, and lethargy leading to coma.

Methixen [German] Patient Information