Tremonil
Brand names,
Tremonil
Analogs
Tremonil
Brand Names Mixture
Tremonil
Chemical_Formula
C16H16ClN3O3S
Tremonil
RX_link
http://www.rxlist.com/cgi/generic2/metolazone.htm
Tremonil
fda sheet
Tremonil
msds (material safety sheet)
Tremonil
Synthesis Reference
No information avaliable
Tremonil
Molecular Weight
365.835 g/mol
Tremonil
Melting Point
256 oC
Tremonil
H2O Solubility
60.3 mg/L
Tremonil
State
Solid
Tremonil
LogP
2.784
Tremonil
Dosage Forms
Tablet for oral administration (0.5mg)
Tremonil
Indication
For the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class.
Tremonil
Pharmacology
Metolazone is a quinazoline diuretic, with properties generally similar to the thiazide diuretics. A proximal action of metolazone has been shown in humans by increased excretion of phosphate and magnesium ions and by a markedly increased fractional excretion of sodium in patients with severely compromised glomerular filtration. This action has been demonstrated in animals by micropuncture studies.
Tremonil
Absorption
Peak blood levels are obtained within 2 to 4 hours of oral administration.
Tremonil
side effects and Toxicity
Symptoms of overdose include difficulty breathing, dizziness, dizziness on standing up, drowsiness, fainting, irritation of the stomach and intestines, and lethargy leading to coma.
Tremonil
Patient Information
No information avaliable
Tremonil
Organisms Affected
Humans and other mammals