Methixart
Brand names,
Methixart
Analogs
Methixart
Brand Names Mixture
Methixart
Chemical_Formula
C16H16ClN3O3S
Methixart
RX_link
http://www.rxlist.com/cgi/generic2/metolazone.htm
Methixart
fda sheet
Methixart
msds (material safety sheet)
Methixart
Synthesis Reference
No information avaliable
Methixart
Molecular Weight
365.835 g/mol
Methixart
Melting Point
256 oC
Methixart
H2O Solubility
60.3 mg/L
Methixart
State
Solid
Methixart
LogP
2.784
Methixart
Dosage Forms
Tablet for oral administration (0.5mg)
Methixart
Indication
For the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class.
Methixart
Pharmacology
Metolazone is a quinazoline diuretic, with properties generally similar to the thiazide diuretics. A proximal action of metolazone has been shown in humans by increased excretion of phosphate and magnesium ions and by a markedly increased fractional excretion of sodium in patients with severely compromised glomerular filtration. This action has been demonstrated in animals by micropuncture studies.
Methixart
Absorption
Peak blood levels are obtained within 2 to 4 hours of oral administration.
Methixart
side effects and Toxicity
Symptoms of overdose include difficulty breathing, dizziness, dizziness on standing up, drowsiness, fainting, irritation of the stomach and intestines, and lethargy leading to coma.
Methixart
Patient Information
No information avaliable
Methixart
Organisms Affected
Humans and other mammals