Tremaril
Brand names,
Tremaril
Analogs
Tremaril
Brand Names Mixture
Tremaril
Chemical_Formula
C16H16ClN3O3S
Tremaril
RX_link
http://www.rxlist.com/cgi/generic2/metolazone.htm
Tremaril
fda sheet
Tremaril
msds (material safety sheet)
Tremaril
Synthesis Reference
No information avaliable
Tremaril
Molecular Weight
365.835 g/mol
Tremaril
Melting Point
256 oC
Tremaril
H2O Solubility
60.3 mg/L
Tremaril
State
Solid
Tremaril
LogP
2.784
Tremaril
Dosage Forms
Tablet for oral administration (0.5mg)
Tremaril
Indication
For the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class.
Tremaril
Pharmacology
Metolazone is a quinazoline diuretic, with properties generally similar to the thiazide diuretics. A proximal action of metolazone has been shown in humans by increased excretion of phosphate and magnesium ions and by a markedly increased fractional excretion of sodium in patients with severely compromised glomerular filtration. This action has been demonstrated in animals by micropuncture studies.
Tremaril
Absorption
Peak blood levels are obtained within 2 to 4 hours of oral administration.
Tremaril
side effects and Toxicity
Symptoms of overdose include difficulty breathing, dizziness, dizziness on standing up, drowsiness, fainting, irritation of the stomach and intestines, and lethargy leading to coma.
Tremaril
Patient Information
No information avaliable
Tremaril
Organisms Affected
Humans and other mammals