Tremaril hydrochloride
Brand names,
Tremaril hydrochloride
Analogs
Tremaril hydrochloride
Brand Names Mixture
Tremaril hydrochloride
Chemical_Formula
C16H16ClN3O3S
Tremaril hydrochloride
RX_link
http://www.rxlist.com/cgi/generic2/metolazone.htm
Tremaril hydrochloride
fda sheet
Tremaril hydrochloride
msds (material safety sheet)
Tremaril hydrochloride
Synthesis Reference
No information avaliable
Tremaril hydrochloride
Molecular Weight
365.835 g/mol
Tremaril hydrochloride
Melting Point
256 oC
Tremaril hydrochloride
H2O Solubility
60.3 mg/L
Tremaril hydrochloride
State
Solid
Tremaril hydrochloride
LogP
2.784
Tremaril hydrochloride
Dosage Forms
Tablet for oral administration (0.5mg)
Tremaril hydrochloride
Indication
For the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class.
Tremaril hydrochloride
Pharmacology
Metolazone is a quinazoline diuretic, with properties generally similar to the thiazide diuretics. A proximal action of metolazone has been shown in humans by increased excretion of phosphate and magnesium ions and by a markedly increased fractional excretion of sodium in patients with severely compromised glomerular filtration. This action has been demonstrated in animals by micropuncture studies.
Tremaril hydrochloride
Absorption
Peak blood levels are obtained within 2 to 4 hours of oral administration.
Tremaril hydrochloride
side effects and Toxicity
Symptoms of overdose include difficulty breathing, dizziness, dizziness on standing up, drowsiness, fainting, irritation of the stomach and intestines, and lethargy leading to coma.
Tremaril hydrochloride
Patient Information
No information avaliable
Tremaril hydrochloride
Organisms Affected
Humans and other mammals