Methylphenetoin
Methylphenetoin Brand names, Methylphenetoin Analogs
Methylphenetoin Brand Names Mixture
- No information avaliable
Methylphenetoin Chemical_Formula
C12H14N2O2
Methylphenetoin RX_link
No information avaliable
Methylphenetoin fda sheet
Methylphenetoin msds (material safety sheet)
Methylphenetoin Synthesis Reference
No information avaliable
Methylphenetoin Molecular Weight
218.252 g/mol
Methylphenetoin Melting Point
135 oC
Methylphenetoin H2O Solubility
1270 mg/L
Methylphenetoin State
Solid
Methylphenetoin LogP
1.515
Methylphenetoin Dosage Forms
Tablet
Methylphenetoin Indication
For the treatment of refractory partial epilepsy.
Methylphenetoin Pharmacology
Mephenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, mephenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of posttetanic potentiation at synapses. Loss of posttetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas. Mephenytoin reduces the maximal activity of brain stem centers responsible for the tonic phase of tonic-clonic (grand mal) seizures.
Methylphenetoin Absorption
No information avaliable
Methylphenetoin side effects and Toxicity
No information avaliable
Methylphenetoin Patient Information
Patient Information:
Discuss with your doctor about the risks of taking Mephenytoin. Mephenytoin may
pass into the breast milk. If you are breast feeding or have any other medical condition,
make sure you let the doctor know.
Alcohol and some other medications may affect the effect of Mephenytoin.
Do not change dose and dosing schedule without consulting your doctor.
Discuss with your doctor about the risks of taking Mephenytoin. Mephenytoin may
pass into the breast milk. If you are breast feeding or have any other medical condition,
make sure you let the doctor know.
Alcohol and some other medications may affect the effect of Mephenytoin.
Do not change dose and dosing schedule without consulting your doctor.
Methylphenetoin Organisms Affected
Humans and other mammals
