Insulton
Brand names,
Insulton
Analogs
Insulton
Brand Names Mixture
Insulton
Chemical_Formula
C12H14N2O2
Insulton
RX_link
No information avaliable
Insulton
fda sheet
Insulton
msds (material safety sheet)
Insulton
Synthesis Reference
No information avaliable
Insulton
Molecular Weight
218.252 g/mol
Insulton
Melting Point
135 oC
Insulton
H2O Solubility
1270 mg/L
Insulton
State
Solid
Insulton
LogP
1.515
Insulton
Dosage Forms
Tablet
Insulton
Indication
For the treatment of refractory partial epilepsy.
Insulton
Pharmacology
Mephenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, mephenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of posttetanic potentiation at synapses. Loss of posttetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas. Mephenytoin reduces the maximal activity of brain stem centers responsible for the tonic phase of tonic-clonic (grand mal) seizures.
Insulton
Absorption
No information avaliable
Insulton
side effects and Toxicity
No information avaliable
Insulton
Patient Information
Patient Information:
Discuss with your doctor about the risks of taking Mephenytoin. Mephenytoin may
pass into the breast milk. If you are breast feeding or have any other medical condition,
make sure you let the doctor know.
Alcohol and some other medications may affect the effect of Mephenytoin.
Do not change dose and dosing schedule without consulting your doctor.
Insulton
Organisms Affected
Humans and other mammals