Methyl Hydantoin
Methyl Hydantoin Brand names, Methyl Hydantoin Analogs
Methyl Hydantoin Brand Names Mixture
- No information avaliable
Methyl Hydantoin Chemical_Formula
C12H14N2O2
Methyl Hydantoin RX_link
No information avaliable
Methyl Hydantoin fda sheet
Methyl Hydantoin msds (material safety sheet)
Methyl Hydantoin Synthesis Reference
No information avaliable
Methyl Hydantoin Molecular Weight
218.252 g/mol
Methyl Hydantoin Melting Point
135 oC
Methyl Hydantoin H2O Solubility
1270 mg/L
Methyl Hydantoin State
Solid
Methyl Hydantoin LogP
1.515
Methyl Hydantoin Dosage Forms
Tablet
Methyl Hydantoin Indication
For the treatment of refractory partial epilepsy.
Methyl Hydantoin Pharmacology
Mephenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, mephenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of posttetanic potentiation at synapses. Loss of posttetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas. Mephenytoin reduces the maximal activity of brain stem centers responsible for the tonic phase of tonic-clonic (grand mal) seizures.
Methyl Hydantoin Absorption
No information avaliable
Methyl Hydantoin side effects and Toxicity
No information avaliable
Methyl Hydantoin Patient Information
Patient Information:
Discuss with your doctor about the risks of taking Mephenytoin. Mephenytoin may
pass into the breast milk. If you are breast feeding or have any other medical condition,
make sure you let the doctor know.
Alcohol and some other medications may affect the effect of Mephenytoin.
Do not change dose and dosing schedule without consulting your doctor.
Discuss with your doctor about the risks of taking Mephenytoin. Mephenytoin may
pass into the breast milk. If you are breast feeding or have any other medical condition,
make sure you let the doctor know.
Alcohol and some other medications may affect the effect of Mephenytoin.
Do not change dose and dosing schedule without consulting your doctor.
Methyl Hydantoin Organisms Affected
Humans and other mammals
