PharmacyCodes



Methoin en es it fr

Methoin Brand names, Methoin Analogs

Methoin Brand Names Mixture

  • No information avaliable

Methoin Chemical_Formula

C12H14N2O2

Methoin RX_link

No information avaliable

Methoin fda sheet

Methoin msds (material safety sheet)

Methoin Synthesis Reference

No information avaliable

Methoin Molecular Weight

218.252 g/mol

Methoin Melting Point

135 oC

Methoin H2O Solubility

1270 mg/L

Methoin State

Solid

Methoin LogP

1.515

Methoin Dosage Forms

Tablet

Methoin Indication

For the treatment of refractory partial epilepsy.

Methoin Pharmacology

Mephenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, mephenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of posttetanic potentiation at synapses. Loss of posttetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas. Mephenytoin reduces the maximal activity of brain stem centers responsible for the tonic phase of tonic-clonic (grand mal) seizures.

Methoin Absorption

No information avaliable

Methoin side effects and Toxicity

No information avaliable

Methoin Patient Information

Patient Information:

Discuss with your doctor about the risks of taking Mephenytoin. Mephenytoin may
pass into the breast milk. If you are breast feeding or have any other medical condition,
make sure you let the doctor know.
Alcohol and some other medications may affect the effect of Mephenytoin.
Do not change dose and dosing schedule without consulting your doctor.

Methoin Organisms Affected

Humans and other mammals