Metaraminol Bitartrate
Metaraminol Bitartrate Brand names, Metaraminol Bitartrate Analogs
Metaraminol Bitartrate Brand Names Mixture
- No information avaliable
Metaraminol Bitartrate Chemical_Formula
C9H13NO2
Metaraminol Bitartrate RX_link
http://www.rxlist.com/cgi/generic2/metar.htm
Metaraminol Bitartrate fda sheet
Metaraminol Bitartrate msds (material safety sheet)
Metaraminol Bitartrate Synthesis Reference
Brit. pat. 353,361 (1930 to I. G. Farben); Brit. pat. 396,951 (1932 to I. G. Farben); Swiss pat. 162,267 (1931 to I. G. Farben); U.S. pats. 1,948,162 ans 1,951,302; Hartung, U.S. pat. 1,995,709 (1935 to Sharp & Dohme)
Metaraminol Bitartrate Molecular Weight
167.205 g/mol
Metaraminol Bitartrate Melting Point
107.5 oC
Metaraminol Bitartrate H2O Solubility
1000 g/L
Metaraminol Bitartrate State
Solid
Metaraminol Bitartrate LogP
0.6
Metaraminol Bitartrate Dosage Forms
Intramuscular injection; Intravenous injection
Metaraminol Bitartrate Indication
For the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage
Metaraminol Bitartrate Pharmacology
Metaraminol is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. Metaraminol is indicated for prevention and treatment of the acute hypotensive state occurring with spinal anesthesia. It is also indicated as adjunctive treatment of hypotension due to hemorrhage, reactions to medications, surgical complications, and shock associated with brain damage due to trauma or tumor. Metaraminol acts on both α1-adrenergic receptors but appears to have no effect on β-adrenergic receptors. It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels.
Metaraminol Bitartrate Absorption
The effect starts 1-2 min after IV injection, 10 min after IM injection, 5-20 min after subcutaneous injection.
Metaraminol Bitartrate side effects and Toxicity
LD50=240 mg/kg (rat, oral); LD50=99 mg/kg (mouse, oral)
Metaraminol Bitartrate Patient Information
Metaraminol Bitartrate Organisms Affected
Humans and other mammals
