Hydroxynorephedrine en es it fr

Hydroxynorephedrine Brand names, Hydroxynorephedrine Analogs

Hydroxynorephedrine Brand Names Mixture

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Hydroxynorephedrine Chemical_Formula


Hydroxynorephedrine RX_link


Hydroxynorephedrine fda sheet

Hydroxynorephedrine msds (material safety sheet)

Hydroxynorephedrine MSDS

Hydroxynorephedrine Synthesis Reference

Brit. pat. 353,361 (1930 to I. G. Farben); Brit. pat. 396,951 (1932 to I. G. Farben); Swiss pat. 162,267 (1931 to I. G. Farben); U.S. pats. 1,948,162 ans 1,951,302; Hartung, U.S. pat. 1,995,709 (1935 to Sharp & Dohme)

Hydroxynorephedrine Molecular Weight

167.205 g/mol

Hydroxynorephedrine Melting Point

107.5 oC

Hydroxynorephedrine H2O Solubility

1000 g/L

Hydroxynorephedrine State


Hydroxynorephedrine LogP


Hydroxynorephedrine Dosage Forms

Intramuscular injection; Intravenous injection

Hydroxynorephedrine Indication

For the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage

Hydroxynorephedrine Pharmacology

Metaraminol is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. Metaraminol is indicated for prevention and treatment of the acute hypotensive state occurring with spinal anesthesia. It is also indicated as adjunctive treatment of hypotension due to hemorrhage, reactions to medications, surgical complications, and shock associated with brain damage due to trauma or tumor. Metaraminol acts on both α1-adrenergic receptors but appears to have no effect on β-adrenergic receptors. It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels.

Hydroxynorephedrine Absorption

The effect starts 1-2 min after IV injection, 10 min after IM injection, 5-20 min after subcutaneous injection.

Hydroxynorephedrine side effects and Toxicity

LD50=240 mg/kg (rat, oral); LD50=99 mg/kg (mouse, oral)

Hydroxynorephedrine Patient Information

Hydroxynorephedrine Organisms Affected

Humans and other mammals