Aramine
Aramine Brand names, Aramine Analogs
Aramine Brand Names Mixture
- No information avaliable
Aramine Chemical_Formula
C9H13NO2
Aramine RX_link
http://www.rxlist.com/cgi/generic2/metar.htm
Aramine fda sheet
Aramine msds (material safety sheet)
Aramine Synthesis Reference
Brit. pat. 353,361 (1930 to I. G. Farben); Brit. pat. 396,951 (1932 to I. G. Farben); Swiss pat. 162,267 (1931 to I. G. Farben); U.S. pats. 1,948,162 ans 1,951,302; Hartung, U.S. pat. 1,995,709 (1935 to Sharp & Dohme)
Aramine Molecular Weight
167.205 g/mol
Aramine Melting Point
107.5 oC
Aramine H2O Solubility
1000 g/L
Aramine State
Solid
Aramine LogP
0.6
Aramine Dosage Forms
Intramuscular injection; Intravenous injection
Aramine Indication
For the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage
Aramine Pharmacology
Metaraminol is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. Metaraminol is indicated for prevention and treatment of the acute hypotensive state occurring with spinal anesthesia. It is also indicated as adjunctive treatment of hypotension due to hemorrhage, reactions to medications, surgical complications, and shock associated with brain damage due to trauma or tumor. Metaraminol acts on both α1-adrenergic receptors but appears to have no effect on β-adrenergic receptors. It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels.
Aramine Absorption
The effect starts 1-2 min after IV injection, 10 min after IM injection, 5-20 min after subcutaneous injection.
Aramine side effects and Toxicity
LD50=240 mg/kg (rat, oral); LD50=99 mg/kg (mouse, oral)
Aramine Patient Information
Aramine Organisms Affected
Humans and other mammals
