Metaradrine
Metaradrine Brand names, Metaradrine Analogs
Metaradrine Brand Names Mixture
- No information avaliable
Metaradrine Chemical_Formula
C9H13NO2
Metaradrine RX_link
http://www.rxlist.com/cgi/generic2/metar.htm
Metaradrine fda sheet
Metaradrine msds (material safety sheet)
Metaradrine Synthesis Reference
Brit. pat. 353,361 (1930 to I. G. Farben); Brit. pat. 396,951 (1932 to I. G. Farben); Swiss pat. 162,267 (1931 to I. G. Farben); U.S. pats. 1,948,162 ans 1,951,302; Hartung, U.S. pat. 1,995,709 (1935 to Sharp & Dohme)
Metaradrine Molecular Weight
167.205 g/mol
Metaradrine Melting Point
107.5 oC
Metaradrine H2O Solubility
1000 g/L
Metaradrine State
Solid
Metaradrine LogP
0.6
Metaradrine Dosage Forms
Intramuscular injection; Intravenous injection
Metaradrine Indication
For the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage
Metaradrine Pharmacology
Metaraminol is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. Metaraminol is indicated for prevention and treatment of the acute hypotensive state occurring with spinal anesthesia. It is also indicated as adjunctive treatment of hypotension due to hemorrhage, reactions to medications, surgical complications, and shock associated with brain damage due to trauma or tumor. Metaraminol acts on both α1-adrenergic receptors but appears to have no effect on β-adrenergic receptors. It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels.
Metaradrine Absorption
The effect starts 1-2 min after IV injection, 10 min after IM injection, 5-20 min after subcutaneous injection.
Metaradrine side effects and Toxicity
LD50=240 mg/kg (rat, oral); LD50=99 mg/kg (mouse, oral)
Metaradrine Patient Information
Metaradrine Organisms Affected
Humans and other mammals
