Icoral B
Icoral B Brand names, Icoral B Analogs
Icoral B Brand Names Mixture
- No information avaliable
Icoral B Chemical_Formula
C9H13NO2
Icoral B RX_link
http://www.rxlist.com/cgi/generic2/metar.htm
Icoral B fda sheet
Icoral B msds (material safety sheet)
Icoral B Synthesis Reference
Brit. pat. 353,361 (1930 to I. G. Farben); Brit. pat. 396,951 (1932 to I. G. Farben); Swiss pat. 162,267 (1931 to I. G. Farben); U.S. pats. 1,948,162 ans 1,951,302; Hartung, U.S. pat. 1,995,709 (1935 to Sharp & Dohme)
Icoral B Molecular Weight
167.205 g/mol
Icoral B Melting Point
107.5 oC
Icoral B H2O Solubility
1000 g/L
Icoral B State
Solid
Icoral B LogP
0.6
Icoral B Dosage Forms
Intramuscular injection; Intravenous injection
Icoral B Indication
For the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage
Icoral B Pharmacology
Metaraminol is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. Metaraminol is indicated for prevention and treatment of the acute hypotensive state occurring with spinal anesthesia. It is also indicated as adjunctive treatment of hypotension due to hemorrhage, reactions to medications, surgical complications, and shock associated with brain damage due to trauma or tumor. Metaraminol acts on both α1-adrenergic receptors but appears to have no effect on β-adrenergic receptors. It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels.
Icoral B Absorption
The effect starts 1-2 min after IV injection, 10 min after IM injection, 5-20 min after subcutaneous injection.
Icoral B side effects and Toxicity
LD50=240 mg/kg (rat, oral); LD50=99 mg/kg (mouse, oral)
Icoral B Patient Information
Icoral B Organisms Affected
Humans and other mammals
