M-Hydroxypropadrine

M-Hydroxypropadrine Brand names, M-Hydroxypropadrine Analogs

M-Hydroxypropadrine Brand Names Mixture

No information avaliable

M-Hydroxypropadrine Chemical_Formula

C₉H₁₃NO₂

M-Hydroxypropadrine RX_link

http://www.rxlist.com/cgi/generic2/metar.htm

M-Hydroxypropadrine fda sheet

M-Hydroxypropadrine msds (material safety sheet)

M-Hydroxypropadrine MSDS

M-Hydroxypropadrine Synthesis Reference

Brit. pat. 353,361 (1930 to I. G. Farben); Brit. pat. 396,951 (1932 to I. G. Farben); Swiss pat. 162,267 (1931 to I. G. Farben); U.S. pats. 1,948,162 ans 1,951,302; Hartung, U.S. pat. 1,995,709 (1935 to Sharp & Dohme)

M-Hydroxypropadrine Molecular Weight

167.205 g/mol

M-Hydroxypropadrine Melting Point

107.5 ^oC

M-Hydroxypropadrine H₂O Solubility

1000 g/L

M-Hydroxypropadrine State

Solid

M-Hydroxypropadrine LogP

0.6

M-Hydroxypropadrine Dosage Forms

Intramuscular injection; Intravenous injection

M-Hydroxypropadrine Indication

For the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage

M-Hydroxypropadrine Pharmacology

Metaraminol is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. Metaraminol is indicated for prevention and treatment of the acute hypotensive state occurring with spinal anesthesia. It is also indicated as adjunctive treatment of hypotension due to hemorrhage, reactions to medications, surgical complications, and shock associated with brain damage due to trauma or tumor. Metaraminol acts on both α1-adrenergic receptors but appears to have no effect on β-adrenergic receptors. It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels.

M-Hydroxypropadrine Absorption

The effect starts 1-2 min after IV injection, 10 min after IM injection, 5-20 min after subcutaneous injection.

M-Hydroxypropadrine side effects and Toxicity

LD₅₀=240 mg/kg (rat, oral); LD₅₀=99 mg/kg (mouse, oral)

M-Hydroxypropadrine Patient Information

M-Hydroxypropadrine Organisms Affected

Humans and other mammals