Foscarnet
Foscarnet Brand names, Foscarnet Analogs
Foscarnet Brand Names Mixture
- No information avaliable
Foscarnet Chemical_Formula
CH3O5P
Foscarnet RX_link
http://www.rxlist.com/cgi/generic2/foscarnet.htm
Foscarnet fda sheet
Foscarnet msds (material safety sheet)
Foscarnet Synthesis Reference
Noren, Jan O.; et al., J.Med.Chem. 26(2) 264-270(1983)
Foscarnet Molecular Weight
126.005 g/mol
Foscarnet Melting Point
88.06 oC
Foscarnet H2O Solubility
Complete
Foscarnet State
Solid
Foscarnet LogP
No information avaliable
Foscarnet Dosage Forms
Injection
Foscarnet Indication
For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.
Foscarnet Pharmacology
Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Foscarnet does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to foscarnet. However, acyclovir or ganciclovir resistant mutants with alterations in the viral DNA polymerase may be resistant to foscarnet and may not respond to therapy with foscarnet. The combination of foscarnet and ganciclovir has been shown to have enhanced activity in vitro.
Foscarnet Absorption
Poorly absorbed after oral administration (bioavailability from 12 to 22%).
Foscarnet side effects and Toxicity
Oral, rat LD50: >2,000 mg/kg. Signs of overdose include renal impairment.
Foscarnet Patient Information
Foscarnet Organisms Affected
Human herpes viruses
