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Foscarnet Brand names, Foscarnet Analogs

Foscarnet Brand Names Mixture

  • No information avaliable

Foscarnet Chemical_Formula


Foscarnet RX_link

Foscarnet fda sheet

Foscarnet msds (material safety sheet)

Foscarnet MSDS

Foscarnet Synthesis Reference

Noren, Jan O.; et al., J.Med.Chem. 26(2) 264-270(1983)

Foscarnet Molecular Weight

126.005 g/mol

Foscarnet Melting Point

88.06 oC

Foscarnet H2O Solubility


Foscarnet State


Foscarnet LogP

No information avaliable

Foscarnet Dosage Forms


Foscarnet Indication

For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.

Foscarnet Pharmacology

Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Foscarnet does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to foscarnet. However, acyclovir or ganciclovir resistant mutants with alterations in the viral DNA polymerase may be resistant to foscarnet and may not respond to therapy with foscarnet. The combination of foscarnet and ganciclovir has been shown to have enhanced activity in vitro.

Foscarnet Absorption

Poorly absorbed after oral administration (bioavailability from 12 to 22%).

Foscarnet side effects and Toxicity

Oral, rat LD50: >2,000 mg/kg. Signs of overdose include renal impairment.

Foscarnet Patient Information

Foscarnet Organisms Affected

Human herpes viruses