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Floxuridine Brand names, Floxuridine Analogs

Floxuridine Brand Names Mixture

  • No information avaliable

Floxuridine Chemical_Formula


Floxuridine RX_link


Floxuridine fda sheet


Floxuridine msds (material safety sheet)

Floxuridine MSDS

Floxuridine Synthesis Reference

No information avaliable

Floxuridine Molecular Weight

246.193 g/mol

Floxuridine Melting Point

150.5 oC

Floxuridine H2O Solubility

1.19E+004 mg/L

Floxuridine State


Floxuridine LogP


Floxuridine Dosage Forms

Powder for solution (500mg vial)

Floxuridine Indication

For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.

Floxuridine Pharmacology

Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.

Floxuridine Absorption

No information avaliable

Floxuridine side effects and Toxicity

Oral, rat LD50: 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis).

Floxuridine Patient Information

Floxuridine Organisms Affected

Humans and other mammals