Floxuridine
Floxuridine Brand names, Floxuridine Analogs
Floxuridine Brand Names Mixture
- No information avaliable
Floxuridine Chemical_Formula
C9H11FN2O5
Floxuridine RX_link
http://www.rxlist.com/cgi/generic2/floxuridine.htm
Floxuridine fda sheet
Floxuridine msds (material safety sheet)
Floxuridine Synthesis Reference
No information avaliable
Floxuridine Molecular Weight
246.193 g/mol
Floxuridine Melting Point
150.5 oC
Floxuridine H2O Solubility
1.19E+004 mg/L
Floxuridine State
Solid
Floxuridine LogP
-1.249
Floxuridine Dosage Forms
Powder for solution (500mg vial)
Floxuridine Indication
For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.
Floxuridine Pharmacology
Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.
Floxuridine Absorption
No information avaliable
Floxuridine side effects and Toxicity
Oral, rat LD50: 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis).
Floxuridine Patient Information
Floxuridine Organisms Affected
Humans and other mammals
