D-Chloramphenicol

D-Chloramphenicol Brand names, D-Chloramphenicol Analogs

D-Chloramphenicol Brand Names Mixture

No information avaliable

D-Chloramphenicol Chemical_Formula

C₁₁H₁₂Cl₂N₂O₅

D-Chloramphenicol RX_link

http://www.rxlist.com/cgi/generic3/chloramphenicol.htm

D-Chloramphenicol fda sheet

D-Chloramphenicol FDA

D-Chloramphenicol msds (material safety sheet)

D-Chloramphenicol MSDS

D-Chloramphenicol Synthesis Reference

No information avaliable

D-Chloramphenicol Molecular Weight

323.129 g/mol

D-Chloramphenicol Melting Point

150.5 ^oC

D-Chloramphenicol H₂O Solubility

2500 mg/L (at 25 °C)

D-Chloramphenicol State

Solid

D-Chloramphenicol LogP

1.476

D-Chloramphenicol Dosage Forms

Capsule; Drops; Liquid; Ointment; Powder; Solution; Suspension; Tablet

D-Chloramphenicol Indication

Used in treatment of cholera, as it destroys the vibrios and decreases the diarrhea. It is effective against tetracycline-resistant vibrios. It is also used in eye drops or ointment to treat bacterial conjunctivitis.

D-Chloramphenicol Pharmacology

Chloramphenicol is a broad-spectrum antibiotic that was derived from the bacterium Streptomyces venezuelae and is now produced synthetically. Chloramphenicol is effective against a wide variety of microorganisms, but due to serious side-effects (e.g., damage to the bone marrow, including aplastic anemia) in humans, it is usually reserved for the treatment of serious and life-threatening infections (e.g., typhoid fever). Chloramphenicol is bacteriostatic but may be bactericidal in high concentrations or when used against highly susceptible organisms. Chloramphenicol stops bacterial growth by binding to the bacterial ribosome (blocking peptidyl transferase) and inhibiting protein synthesis.

D-Chloramphenicol Absorption

Rapidly and completely absorbed from gastrointestinal tract following oral administration (bioavailability 80%). Well absorbed following intramuscular administration (bioavailability 70%). Intraocular and some systemic absorption also occurs after topical application to the eye.

D-Chloramphenicol side effects and Toxicity

Oral, mouse: LD₅₀ = 1500 mg/kg; Oral, rat: LD₅₀ = 2500 mg/kg. Toxic reactions including fatalities have occurred in the premature and newborn; the signs and symptoms associated with these reactions have been referred to as the gray syndrome. Symptoms include (in order of appearance) abdominal distension with or without emesis, progressive pallid cyanosis, vasomotor collapse frequently accompanied by irregular respiration, and death within a few hours of onset of these symptoms.

D-Chloramphenicol Patient Information