Sopamycetin Ophthalmic Ointment

Sopamycetin Ophthalmic Ointment Brand names, Sopamycetin Ophthalmic Ointment Analogs

Sopamycetin Ophthalmic Ointment Brand Names Mixture

No information avaliable

Sopamycetin Ophthalmic Ointment Chemical_Formula

C₁₁H₁₂Cl₂N₂O₅

Sopamycetin Ophthalmic Ointment RX_link

http://www.rxlist.com/cgi/generic3/chloramphenicol.htm

Sopamycetin Ophthalmic Ointment fda sheet

Sopamycetin_Ophthalmic_Ointment FDA

Sopamycetin Ophthalmic Ointment msds (material safety sheet)

Sopamycetin_Ophthalmic_Ointment MSDS

Sopamycetin Ophthalmic Ointment Synthesis Reference

No information avaliable

Sopamycetin Ophthalmic Ointment Molecular Weight

323.129 g/mol

Sopamycetin Ophthalmic Ointment Melting Point

150.5 ^oC

Sopamycetin Ophthalmic Ointment H₂O Solubility

2500 mg/L (at 25 °C)

Sopamycetin Ophthalmic Ointment State

Solid

Sopamycetin Ophthalmic Ointment LogP

1.476

Sopamycetin Ophthalmic Ointment Dosage Forms

Capsule; Drops; Liquid; Ointment; Powder; Solution; Suspension; Tablet

Sopamycetin Ophthalmic Ointment Indication

Used in treatment of cholera, as it destroys the vibrios and decreases the diarrhea. It is effective against tetracycline-resistant vibrios. It is also used in eye drops or ointment to treat bacterial conjunctivitis.

Sopamycetin Ophthalmic Ointment Pharmacology

Chloramphenicol is a broad-spectrum antibiotic that was derived from the bacterium Streptomyces venezuelae and is now produced synthetically. Chloramphenicol is effective against a wide variety of microorganisms, but due to serious side-effects (e.g., damage to the bone marrow, including aplastic anemia) in humans, it is usually reserved for the treatment of serious and life-threatening infections (e.g., typhoid fever). Chloramphenicol is bacteriostatic but may be bactericidal in high concentrations or when used against highly susceptible organisms. Chloramphenicol stops bacterial growth by binding to the bacterial ribosome (blocking peptidyl transferase) and inhibiting protein synthesis.

Sopamycetin Ophthalmic Ointment Absorption

Rapidly and completely absorbed from gastrointestinal tract following oral administration (bioavailability 80%). Well absorbed following intramuscular administration (bioavailability 70%). Intraocular and some systemic absorption also occurs after topical application to the eye.

Sopamycetin Ophthalmic Ointment side effects and Toxicity

Oral, mouse: LD₅₀ = 1500 mg/kg; Oral, rat: LD₅₀ = 2500 mg/kg. Toxic reactions including fatalities have occurred in the premature and newborn; the signs and symptoms associated with these reactions have been referred to as the gray syndrome. Symptoms include (in order of appearance) abdominal distension with or without emesis, progressive pallid cyanosis, vasomotor collapse frequently accompanied by irregular respiration, and death within a few hours of onset of these symptoms.

Sopamycetin Ophthalmic Ointment Patient Information