Doctamicina

Doctamicina Brand names, Doctamicina Analogs

Doctamicina Brand Names Mixture

No information avaliable

Doctamicina Chemical_Formula

C₁₁H₁₂Cl₂N₂O₅

Doctamicina RX_link

http://www.rxlist.com/cgi/generic3/chloramphenicol.htm

Doctamicina fda sheet

Doctamicina FDA

Doctamicina msds (material safety sheet)

Doctamicina MSDS

Doctamicina Synthesis Reference

No information avaliable

Doctamicina Molecular Weight

323.129 g/mol

Doctamicina Melting Point

150.5 ^oC

Doctamicina H₂O Solubility

2500 mg/L (at 25 °C)

Doctamicina State

Solid

Doctamicina LogP

1.476

Doctamicina Dosage Forms

Capsule; Drops; Liquid; Ointment; Powder; Solution; Suspension; Tablet

Doctamicina Indication

Used in treatment of cholera, as it destroys the vibrios and decreases the diarrhea. It is effective against tetracycline-resistant vibrios. It is also used in eye drops or ointment to treat bacterial conjunctivitis.

Doctamicina Pharmacology

Chloramphenicol is a broad-spectrum antibiotic that was derived from the bacterium Streptomyces venezuelae and is now produced synthetically. Chloramphenicol is effective against a wide variety of microorganisms, but due to serious side-effects (e.g., damage to the bone marrow, including aplastic anemia) in humans, it is usually reserved for the treatment of serious and life-threatening infections (e.g., typhoid fever). Chloramphenicol is bacteriostatic but may be bactericidal in high concentrations or when used against highly susceptible organisms. Chloramphenicol stops bacterial growth by binding to the bacterial ribosome (blocking peptidyl transferase) and inhibiting protein synthesis.

Doctamicina Absorption

Rapidly and completely absorbed from gastrointestinal tract following oral administration (bioavailability 80%). Well absorbed following intramuscular administration (bioavailability 70%). Intraocular and some systemic absorption also occurs after topical application to the eye.

Doctamicina side effects and Toxicity

Oral, mouse: LD₅₀ = 1500 mg/kg; Oral, rat: LD₅₀ = 2500 mg/kg. Toxic reactions including fatalities have occurred in the premature and newborn; the signs and symptoms associated with these reactions have been referred to as the gray syndrome. Symptoms include (in order of appearance) abdominal distension with or without emesis, progressive pallid cyanosis, vasomotor collapse frequently accompanied by irregular respiration, and death within a few hours of onset of these symptoms.

Doctamicina Patient Information