Chloromycetin for Ophthalmic Solution

Chloromycetin for Ophthalmic Solution Brand names, Chloromycetin for Ophthalmic Solution Analogs

Chloromycetin for Ophthalmic Solution Brand Names Mixture

No information avaliable

Chloromycetin for Ophthalmic Solution Chemical_Formula

C₁₁H₁₂Cl₂N₂O₅

Chloromycetin for Ophthalmic Solution RX_link

http://www.rxlist.com/cgi/generic3/chloramphenicol.htm

Chloromycetin for Ophthalmic Solution fda sheet

Chloromycetin_for_Ophthalmic_Solution FDA

Chloromycetin for Ophthalmic Solution msds (material safety sheet)

Chloromycetin_for_Ophthalmic_Solution MSDS

Chloromycetin for Ophthalmic Solution Synthesis Reference

No information avaliable

Chloromycetin for Ophthalmic Solution Molecular Weight

323.129 g/mol

Chloromycetin for Ophthalmic Solution Melting Point

150.5 ^oC

Chloromycetin for Ophthalmic Solution H₂O Solubility

2500 mg/L (at 25 °C)

Chloromycetin for Ophthalmic Solution State

Solid

Chloromycetin for Ophthalmic Solution LogP

1.476

Chloromycetin for Ophthalmic Solution Dosage Forms

Capsule; Drops; Liquid; Ointment; Powder; Solution; Suspension; Tablet

Chloromycetin for Ophthalmic Solution Indication

Used in treatment of cholera, as it destroys the vibrios and decreases the diarrhea. It is effective against tetracycline-resistant vibrios. It is also used in eye drops or ointment to treat bacterial conjunctivitis.

Chloromycetin for Ophthalmic Solution Pharmacology

Chloramphenicol is a broad-spectrum antibiotic that was derived from the bacterium Streptomyces venezuelae and is now produced synthetically. Chloramphenicol is effective against a wide variety of microorganisms, but due to serious side-effects (e.g., damage to the bone marrow, including aplastic anemia) in humans, it is usually reserved for the treatment of serious and life-threatening infections (e.g., typhoid fever). Chloramphenicol is bacteriostatic but may be bactericidal in high concentrations or when used against highly susceptible organisms. Chloramphenicol stops bacterial growth by binding to the bacterial ribosome (blocking peptidyl transferase) and inhibiting protein synthesis.

Chloromycetin for Ophthalmic Solution Absorption

Rapidly and completely absorbed from gastrointestinal tract following oral administration (bioavailability 80%). Well absorbed following intramuscular administration (bioavailability 70%). Intraocular and some systemic absorption also occurs after topical application to the eye.

Chloromycetin for Ophthalmic Solution side effects and Toxicity

Oral, mouse: LD₅₀ = 1500 mg/kg; Oral, rat: LD₅₀ = 2500 mg/kg. Toxic reactions including fatalities have occurred in the premature and newborn; the signs and symptoms associated with these reactions have been referred to as the gray syndrome. Symptoms include (in order of appearance) abdominal distension with or without emesis, progressive pallid cyanosis, vasomotor collapse frequently accompanied by irregular respiration, and death within a few hours of onset of these symptoms.

Chloromycetin for Ophthalmic Solution Patient Information