Pentamycetin Ophthalmic Ointment

Pentamycetin Ophthalmic Ointment Brand names, Pentamycetin Ophthalmic Ointment Analogs

Pentamycetin Ophthalmic Ointment Brand Names Mixture

No information avaliable

Pentamycetin Ophthalmic Ointment Chemical_Formula

C₁₁H₁₂Cl₂N₂O₅

Pentamycetin Ophthalmic Ointment RX_link

http://www.rxlist.com/cgi/generic3/chloramphenicol.htm

Pentamycetin Ophthalmic Ointment fda sheet

Pentamycetin_Ophthalmic_Ointment FDA

Pentamycetin Ophthalmic Ointment msds (material safety sheet)

Pentamycetin_Ophthalmic_Ointment MSDS

Pentamycetin Ophthalmic Ointment Synthesis Reference

No information avaliable

Pentamycetin Ophthalmic Ointment Molecular Weight

323.129 g/mol

Pentamycetin Ophthalmic Ointment Melting Point

150.5 ^oC

Pentamycetin Ophthalmic Ointment H₂O Solubility

2500 mg/L (at 25 °C)

Pentamycetin Ophthalmic Ointment State

Solid

Pentamycetin Ophthalmic Ointment LogP

1.476

Pentamycetin Ophthalmic Ointment Dosage Forms

Capsule; Drops; Liquid; Ointment; Powder; Solution; Suspension; Tablet

Pentamycetin Ophthalmic Ointment Indication

Used in treatment of cholera, as it destroys the vibrios and decreases the diarrhea. It is effective against tetracycline-resistant vibrios. It is also used in eye drops or ointment to treat bacterial conjunctivitis.

Pentamycetin Ophthalmic Ointment Pharmacology

Chloramphenicol is a broad-spectrum antibiotic that was derived from the bacterium Streptomyces venezuelae and is now produced synthetically. Chloramphenicol is effective against a wide variety of microorganisms, but due to serious side-effects (e.g., damage to the bone marrow, including aplastic anemia) in humans, it is usually reserved for the treatment of serious and life-threatening infections (e.g., typhoid fever). Chloramphenicol is bacteriostatic but may be bactericidal in high concentrations or when used against highly susceptible organisms. Chloramphenicol stops bacterial growth by binding to the bacterial ribosome (blocking peptidyl transferase) and inhibiting protein synthesis.

Pentamycetin Ophthalmic Ointment Absorption

Rapidly and completely absorbed from gastrointestinal tract following oral administration (bioavailability 80%). Well absorbed following intramuscular administration (bioavailability 70%). Intraocular and some systemic absorption also occurs after topical application to the eye.

Pentamycetin Ophthalmic Ointment side effects and Toxicity

Oral, mouse: LD₅₀ = 1500 mg/kg; Oral, rat: LD₅₀ = 2500 mg/kg. Toxic reactions including fatalities have occurred in the premature and newborn; the signs and symptoms associated with these reactions have been referred to as the gray syndrome. Symptoms include (in order of appearance) abdominal distension with or without emesis, progressive pallid cyanosis, vasomotor collapse frequently accompanied by irregular respiration, and death within a few hours of onset of these symptoms.

Pentamycetin Ophthalmic Ointment Patient Information