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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C18H37N5O9
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RX_link
http://www.rxlist.com/cgi/generic2/tobi.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Y. Takagi et al., Bull. Chem. Soc. Japan 49, 3649 (1976)
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Molecular Weight
467.515 g/mol
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Melting Point
No information avaliable
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H2O Solubility
1E+003 mg/ml
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State
Solid
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LogP
-6.899
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Dosage Forms
Ophthalmic ointment; Powder for solution; Solution for oral inhalation; Ophthalmic solution; Oral solution; IV solution
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Indication
For the treatment of pseudomonas aeruginosa lung infections
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Pharmacology
Tobramycin, an aminoglycoside antibiotic obtained from cultures of Streptomyces tenebrarius, is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, bacteremia and sepsis, respiratory infections including those associated with cystic fibrosis, osteomyelitis, and diabetic foot and other soft-tissue infections.
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Absorption
No information avaliable
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side effects and Toxicity
LD50=441mg/kg (s.c. in mice)
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Patient Information
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Organisms Affected
Enteric bacteria and other eubacteria