Nebramycin
Brand names,
Nebramycin
Analogs
Nebramycin
Brand Names Mixture
Nebramycin
Chemical_Formula
C18H36N4O11
Nebramycin
RX_link
http://www.rxlist.com/cgi/generic3/kanamycin.htm
Nebramycin
fda sheet
Nebramycin
msds (material safety sheet)
Nebramycin
Synthesis Reference
No information avaliable
Nebramycin
Molecular Weight
484.499 g/mol
Nebramycin
Melting Point
No information avaliable
Nebramycin
H2O Solubility
No information avaliable
Nebramycin
State
Solid
Nebramycin
LogP
-7.936
Nebramycin
Dosage Forms
No information avaliable
Nebramycin
Indication
For treatment of infections where one or more of the following are the known or suspected pathogens: E. coli, Proteus species (both indole-positive and indole-negative), E. aerogenes, K. pneumoniae, S. marcescens, and Acinetobacter species.
Nebramycin
Pharmacology
Kanamycin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.
Nebramycin
Absorption
No information avaliable
Nebramycin
side effects and Toxicity
LD 50 - ORAL, MOUSE = 17500 MG/KG, LD 50 - ORAL, RAT = >4 GM/KG, LD 50 - ORAL, RABBIT = >3 GM/KG
Nebramycin
Patient Information
No information avaliable
Nebramycin
Organisms Affected
Enteric bacteria and other eubacteria