Sibazon
Category
Sibazon Brand names, Sibazon Analogs
Sibazon Brand Names Mixture
Sibazon Chemical_Formula
C16H13ClN2O
Sibazon RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Sibazon fda sheet
Sibazon msds (material safety sheet)
Sibazon Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Sibazon Molecular Weight
284.74 g/mol
Sibazon Melting Point
125-126oC
Sibazon H2O Solubility
Slightly soluble (50 mg/L)
Sibazon State
solid
Sibazon LogP
2.988
Sibazon Dosage Forms
Tablets; Injectable solution
Sibazon Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Sibazon Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Sibazon Absorption
Essentially complete, with a bioavailability of 93%.
Sibazon side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Sibazon Patient Information
Sibazon Organisms Affected
Humans and other mammals
