Kiatrium
Category
Kiatrium Brand names, Kiatrium Analogs
Kiatrium Brand Names Mixture
Kiatrium Chemical_Formula
C16H13ClN2O
Kiatrium RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Kiatrium fda sheet
Kiatrium msds (material safety sheet)
Kiatrium Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Kiatrium Molecular Weight
284.74 g/mol
Kiatrium Melting Point
125-126oC
Kiatrium H2O Solubility
Slightly soluble (50 mg/L)
Kiatrium State
solid
Kiatrium LogP
2.988
Kiatrium Dosage Forms
Tablets; Injectable solution
Kiatrium Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Kiatrium Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Kiatrium Absorption
Essentially complete, with a bioavailability of 93%.
Kiatrium side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Kiatrium Patient Information
Kiatrium Organisms Affected
Humans and other mammals
