Frustan
Category
Frustan Brand names, Frustan Analogs
Frustan Brand Names Mixture
Frustan Chemical_Formula
C16H13ClN2O
Frustan RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Frustan fda sheet
Frustan msds (material safety sheet)
Frustan Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Frustan Molecular Weight
284.74 g/mol
Frustan Melting Point
125-126oC
Frustan H2O Solubility
Slightly soluble (50 mg/L)
Frustan State
solid
Frustan LogP
2.988
Frustan Dosage Forms
Tablets; Injectable solution
Frustan Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Frustan Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Frustan Absorption
Essentially complete, with a bioavailability of 93%.
Frustan side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Frustan Patient Information
Frustan Organisms Affected
Humans and other mammals
