Bensedin
Category
Bensedin Brand names, Bensedin Analogs
Bensedin Brand Names Mixture
Bensedin Chemical_Formula
C16H13ClN2O
Bensedin RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Bensedin fda sheet
Bensedin msds (material safety sheet)
Bensedin Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Bensedin Molecular Weight
284.74 g/mol
Bensedin Melting Point
125-126oC
Bensedin H2O Solubility
Slightly soluble (50 mg/L)
Bensedin State
solid
Bensedin LogP
2.988
Bensedin Dosage Forms
Tablets; Injectable solution
Bensedin Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Bensedin Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Bensedin Absorption
Essentially complete, with a bioavailability of 93%.
Bensedin side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Bensedin Patient Information
Bensedin Organisms Affected
Humans and other mammals
