Categorie
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Les marques,
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Analogs
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Les marques melange
No information avaliable
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Formule chimique
C21H27NO
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RX lien
http://www.rxlist.com/cgi/generic/methdone.htm
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FDA fiche
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msds (fiche de securite des materiaux)
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Synthese de reference
Aucune information disponible
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Poids moleculaire
309.445 g/mol
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Point de fusion
235.0oC
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H2O Solubilite
48,5 mg / L
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Etat
Solid
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LogP
5.458
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Formes pharmaceutiques
Tablet
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Indication
Pour le traitement de la toux sèche, un syndrome de sevrage de drogue, la dépendance aux opiacés type de drogue, et la douleur
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Pharmacologie
La méthadone est un analgésique opioïde synthétique à des actions multiples quantitativement similaires à ceux de la morphine, le plus important de ce qui impliquent le système nerveux central et des organes composés de lisses musculaire. Cependant, la méthadone est plus actif et plus toxique que la morphine. La méthadone est indiqué pour le soulagement de la douleur sévère, pour le traitement de désintoxication de la dépendance aux narcotiques, et pour l'entretien temporaire traitement de la dépendance aux narcotiques. Les principales actions de la valeur thérapeutique sont l'analgésie et la sédation et de désintoxication ou de maintenance temporaire dépendance aux narcotiques. Le syndrome d'abstinence à la méthadone, , Bien que qualitativement semblable à celui de la morphine, diffère en ce que le début est lent, le parcours est plus prolongée, et les symptômes sont moins graves.
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Absorption
Aucune information disponible
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Toxicite
Aucune information disponible
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Information pour les patients
PATIENT INFORMATION
Narcotic analgesics are used to relieve pain. Some of these medicines are also used just before or during an operation to help the anesthetic work better. Codeine and hydrocodone are also used to relieve coughing. Methadone is also used to help some people control their dependence on heroin or other narcotics. Narcotic analgesics may also be used for other conditions as determined by your doctor.
Narcotic analgesics act in the central nervous system (CNS) to relieve pain. Some of their side effects are also caused by actions in the CNS.
If a narcotic is used for a long time, it may become habit-forming (causing mental or physical dependence). Physical dependence may lead to withdrawal side effects when you stop taking the medicine.
These medicines are available only with your medical doctor's or dentist's prescription. For some of them, prescriptions cannot be refilled and you must obtain a new prescription from your medical doctor or dentist each time you need the medicine. In addition, other rules and regulations may apply when methadone is used to treat narcotic dependence.
-Tell your doctor if you have ever had any unusual or allergic reaction to any of the narcotic analgesics. Also tell to your doctor if you are allergic to any other substances, such as foods, preservatives, or dyes.
-Too much use of a narcotic during pregnancy may cause the baby to become dependent on the medicine. This may lead to withdrawal side effects after birth. Also, some of these medicines may cause breathing problems in the newborn
infant if taken just before delivery.
-Most narcotic analgesics have not been reported to cause problems in nursing babies. However, when the mother is taking large amounts of methadone (in a methadone maintenance program), the nursing baby may become dependent on the medicine. Also, butorphanol, codeine, meperidine, morphine, opium, and propoxyphene pass into the breast milk.
-Breathing problems may be especially likely to occur in children younger than 2 years of age. These children are usually more sensitive than adults to the effects of narcotic analgesics. Also, unusual excitement or restlessness may be more likely to occur in children receiving these medicines.
-Elderly people are especially sensitive to the effects of narcotic analgesics. This may increase the chance of side effects, especially breathing problems, during treatment.
-Methadone should be used with caution and in reduced dosage in patients who are concurrently receiving other narcotic analgesics, general anesthetics, phenothiazines, other tranquilizers, sedative-hypnotics, tricyclic antidepressants, and other CNS depressants (including alcohol). Respiratory depression, hypotension, and profound sedation or coma may result.
-Read more about Methadone on:
http://www.rxlist.com/cgi/generic/methdone_wcp.htm
http://www.drugs.com/cons/Methadone.html
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Organismes affectes
Les humains et autres mammifères