Vinorelbine
Vinorelbine Brand names, Vinorelbine Analogs
Vinorelbine Brand Names Mixture
- No information avaliable
Vinorelbine Chemical_Formula
C45H54N4O8
Vinorelbine RX_link
http://www.rxlist.com/cgi/generic2/vinor.htm
Vinorelbine fda sheet
Vinorelbine msds (material safety sheet)
Vinorelbine Synthesis Reference
No information avaliable
Vinorelbine Molecular Weight
778.932 g/mol
Vinorelbine Melting Point
No information avaliable
Vinorelbine H2O Solubility
No information avaliable
Vinorelbine State
Solid
Vinorelbine LogP
5.829
Vinorelbine Dosage Forms
Solution
Vinorelbine Indication
For the treatment of non-small-cell lung carcinoma
Vinorelbine Pharmacology
Vinorelbine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vinorelbine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vinorelbine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
Vinorelbine Absorption
No information avaliable
Vinorelbine side effects and Toxicity
No information avaliable
Vinorelbine Patient Information
No information avaliable
Vinorelbine Organisms Affected
Humans and other mammals
