Navelbine
Navelbine Brand names, Navelbine Analogs
Navelbine Brand Names Mixture
- No information avaliable
Navelbine Chemical_Formula
C45H54N4O8
Navelbine RX_link
http://www.rxlist.com/cgi/generic2/vinor.htm
Navelbine fda sheet
Navelbine msds (material safety sheet)
Navelbine Synthesis Reference
No information avaliable
Navelbine Molecular Weight
778.932 g/mol
Navelbine Melting Point
No information avaliable
Navelbine H2O Solubility
No information avaliable
Navelbine State
Solid
Navelbine LogP
5.829
Navelbine Dosage Forms
Solution
Navelbine Indication
For the treatment of non-small-cell lung carcinoma
Navelbine Pharmacology
Vinorelbine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vinorelbine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vinorelbine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
Navelbine Absorption
No information avaliable
Navelbine side effects and Toxicity
No information avaliable
Navelbine Patient Information
No information avaliable
Navelbine Organisms Affected
Humans and other mammals
