Vinorelbin
Vinorelbin Brand names, Vinorelbin Analogs
Vinorelbin Brand Names Mixture
- No information avaliable
Vinorelbin Chemical_Formula
C45H54N4O8
Vinorelbin RX_link
http://www.rxlist.com/cgi/generic2/vinor.htm
Vinorelbin fda sheet
Vinorelbin msds (material safety sheet)
Vinorelbin Synthesis Reference
No information avaliable
Vinorelbin Molecular Weight
778.932 g/mol
Vinorelbin Melting Point
No information avaliable
Vinorelbin H2O Solubility
No information avaliable
Vinorelbin State
Solid
Vinorelbin LogP
5.829
Vinorelbin Dosage Forms
Solution
Vinorelbin Indication
For the treatment of non-small-cell lung carcinoma
Vinorelbin Pharmacology
Vinorelbine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vinorelbine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vinorelbine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
Vinorelbin Absorption
No information avaliable
Vinorelbin side effects and Toxicity
No information avaliable
Vinorelbin Patient Information
No information avaliable
Vinorelbin Organisms Affected
Humans and other mammals
