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Vinorelbin Brand names, Vinorelbin Analogs

Vinorelbin Brand Names Mixture

  • No information avaliable

Vinorelbin Chemical_Formula

C45H54N4O8

Vinorelbin RX_link

http://www.rxlist.com/cgi/generic2/vinor.htm

Vinorelbin fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=136

Vinorelbin msds (material safety sheet)

Vinorelbin Synthesis Reference

No information avaliable

Vinorelbin Molecular Weight

778.932 g/mol

Vinorelbin Melting Point

No information avaliable

Vinorelbin H2O Solubility

No information avaliable

Vinorelbin State

Solid

Vinorelbin LogP

5.829

Vinorelbin Dosage Forms

Solution

Vinorelbin Indication

For the treatment of non-small-cell lung carcinoma

Vinorelbin Pharmacology

Vinorelbine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vinorelbine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vinorelbine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.

Vinorelbin Absorption

No information avaliable

Vinorelbin side effects and Toxicity

No information avaliable

Vinorelbin Patient Information

No information avaliable

Vinorelbin Organisms Affected

Humans and other mammals