Navelbine Base
Navelbine Base Brand names, Navelbine Base Analogs
Navelbine Base Brand Names Mixture
- No information avaliable
Navelbine Base Chemical_Formula
C45H54N4O8
Navelbine Base RX_link
http://www.rxlist.com/cgi/generic2/vinor.htm
Navelbine Base fda sheet
Navelbine Base msds (material safety sheet)
Navelbine Base Synthesis Reference
No information avaliable
Navelbine Base Molecular Weight
778.932 g/mol
Navelbine Base Melting Point
No information avaliable
Navelbine Base H2O Solubility
No information avaliable
Navelbine Base State
Solid
Navelbine Base LogP
5.829
Navelbine Base Dosage Forms
Solution
Navelbine Base Indication
For the treatment of non-small-cell lung carcinoma
Navelbine Base Pharmacology
Vinorelbine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vinorelbine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vinorelbine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
Navelbine Base Absorption
No information avaliable
Navelbine Base side effects and Toxicity
No information avaliable
Navelbine Base Patient Information
No information avaliable
Navelbine Base Organisms Affected
Humans and other mammals
