Vinorelbinum [Latin]
Vinorelbinum [Latin] Brand names, Vinorelbinum [Latin] Analogs
Vinorelbinum [Latin] Brand Names Mixture
- No information avaliable
Vinorelbinum [Latin] Chemical_Formula
C45H54N4O8
Vinorelbinum [Latin] RX_link
http://www.rxlist.com/cgi/generic2/vinor.htm
Vinorelbinum [Latin] fda sheet
Vinorelbinum [Latin] msds (material safety sheet)
Vinorelbinum [Latin] Synthesis Reference
No information avaliable
Vinorelbinum [Latin] Molecular Weight
778.932 g/mol
Vinorelbinum [Latin] Melting Point
No information avaliable
Vinorelbinum [Latin] H2O Solubility
No information avaliable
Vinorelbinum [Latin] State
Solid
Vinorelbinum [Latin] LogP
5.829
Vinorelbinum [Latin] Dosage Forms
Solution
Vinorelbinum [Latin] Indication
For the treatment of non-small-cell lung carcinoma
Vinorelbinum [Latin] Pharmacology
Vinorelbine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vinorelbine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vinorelbine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
Vinorelbinum [Latin] Absorption
No information avaliable
Vinorelbinum [Latin] side effects and Toxicity
No information avaliable
Vinorelbinum [Latin] Patient Information
No information avaliable
Vinorelbinum [Latin] Organisms Affected
Humans and other mammals
![Vinorelbinum_[Latin]](/images/rx/APRD00101.gif)
