Tsiklamid
Brand names,
Tsiklamid
Analogs
Tsiklamid
Brand Names Mixture
Tsiklamid
Chemical_Formula
C15H20N2O4S
Tsiklamid
RX_link
No information avaliable
Tsiklamid
fda sheet
Tsiklamid
msds (material safety sheet)
Tsiklamid
Synthesis Reference
No information avaliable
Tsiklamid
Molecular Weight
324.396 g/mol
Tsiklamid
Melting Point
188-190 oC
Tsiklamid
H2O Solubility
3430 mg/L
Tsiklamid
State
Solid
Tsiklamid
LogP
2.954
Tsiklamid
Dosage Forms
Tablet (250, 500 mg)
Tsiklamid
Indication
Used in the management of diabetes mellitus type 2 (adult-onset).
Tsiklamid
Pharmacology
Acetohexamide is an intermediate-acting, first-generation oral sulfonylurea. It lowers blood sugar by stimulating the pancreatic beta cells to secrete insulin and by helping the body use insulin efficiently. The pancreas must produce insulin for this medication to work. Acetohexamide has one-third the potency of chlorpropamide, and twice the potency of tolbutamide; however, similar hypoglycemic efficacy occurs with equipotent dosage of sulfonylureas.
Tsiklamid
Absorption
Rapidly absorbed from the GI tract.
Tsiklamid
side effects and Toxicity
Oral, rat LD50: 5 gm/kg; Oral, mouse LD50: >2500 mg/kg. Symptoms of an acetohexamide overdose include hunger, nausea, anxiety, cold sweats, weakness, drowsiness, unconsciousness, and coma.
Tsiklamid
Patient Information
No information avaliable
Tsiklamid
Organisms Affected
Humans and other mammals