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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C15H20N2O4S
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
324.396 g/mol
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Melting Point
188-190 oC
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H2O Solubility
3430 mg/L
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State
Solid
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LogP
2.954
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Dosage Forms
Tablet (250, 500 mg)
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Indication
Used in the management of diabetes mellitus type 2 (adult-onset).
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Pharmacology
Acetohexamide is an intermediate-acting, first-generation oral sulfonylurea. It lowers blood sugar by stimulating the pancreatic beta cells to secrete insulin and by helping the body use insulin efficiently. The pancreas must produce insulin for this medication to work. Acetohexamide has one-third the potency of chlorpropamide, and twice the potency of tolbutamide; however, similar hypoglycemic efficacy occurs with equipotent dosage of sulfonylureas.
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Absorption
Rapidly absorbed from the GI tract.
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side effects and Toxicity
Oral, rat LD50: 5 gm/kg; Oral, mouse LD50: >2500 mg/kg. Symptoms of an acetohexamide overdose include hunger, nausea, anxiety, cold sweats, weakness, drowsiness, unconsciousness, and coma.
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals