Hypoglicil
Brand names,
Hypoglicil
Analogs
Hypoglicil
Brand Names Mixture
Hypoglicil
Chemical_Formula
C15H20N2O4S
Hypoglicil
RX_link
No information avaliable
Hypoglicil
fda sheet
Hypoglicil
msds (material safety sheet)
Hypoglicil
Synthesis Reference
No information avaliable
Hypoglicil
Molecular Weight
324.396 g/mol
Hypoglicil
Melting Point
188-190 oC
Hypoglicil
H2O Solubility
3430 mg/L
Hypoglicil
State
Solid
Hypoglicil
LogP
2.954
Hypoglicil
Dosage Forms
Tablet (250, 500 mg)
Hypoglicil
Indication
Used in the management of diabetes mellitus type 2 (adult-onset).
Hypoglicil
Pharmacology
Acetohexamide is an intermediate-acting, first-generation oral sulfonylurea. It lowers blood sugar by stimulating the pancreatic beta cells to secrete insulin and by helping the body use insulin efficiently. The pancreas must produce insulin for this medication to work. Acetohexamide has one-third the potency of chlorpropamide, and twice the potency of tolbutamide; however, similar hypoglycemic efficacy occurs with equipotent dosage of sulfonylureas.
Hypoglicil
Absorption
Rapidly absorbed from the GI tract.
Hypoglicil
side effects and Toxicity
Oral, rat LD50: 5 gm/kg; Oral, mouse LD50: >2500 mg/kg. Symptoms of an acetohexamide overdose include hunger, nausea, anxiety, cold sweats, weakness, drowsiness, unconsciousness, and coma.
Hypoglicil
Patient Information
No information avaliable
Hypoglicil
Organisms Affected
Humans and other mammals