Tramadol HCl BP/EP

Tramadol HCl BP/EP Brand names, Tramadol HCl BP/EP Analogs

Tramadol HCl BP/EP Brand Names Mixture

No information avaliable

Tramadol HCl BP/EP Chemical_Formula

C₁₆H₂₅NO₂

Tramadol HCl BP/EP RX_link

http://www.rxlist.com/cgi/generic/tramadol.htm

Tramadol HCl BP/EP fda sheet

Tramadol_HCl_BP/EP FDA

Tramadol HCl BP/EP msds (material safety sheet)

Tramadol_HCl_BP/EP MSDS

Tramadol HCl BP/EP Synthesis Reference

K. Flick, E. Frankus, U.S. Pat 3,652,589 (1965)

Tramadol HCl BP/EP Molecular Weight

263.375 g/mol

Tramadol HCl BP/EP Melting Point

180-181^oC

Tramadol HCl BP/EP H₂O Solubility

Soluble in water.

Tramadol HCl BP/EP State

Solid

Tramadol HCl BP/EP LogP

2.951

Tramadol HCl BP/EP Dosage Forms

Tablet

Tramadol HCl BP/EP Indication

Indicated in the treatment of moderate to severe pain.

Tramadol HCl BP/EP Pharmacology

Tramadol, a centrally-acting analgesic, exists as a racemic mixture of the trans isomer, with important differences in binding, activity, and metabolism associated with the two enantiomers. Although Tramadol is a synthetic analog of codeine, it has a significantly lower affinity for opioid receptors than codeine. Tramadol is used to treat postoperative, dental, cancer, and acute musculosketetal pain and as an adjuvant to NSAID therapy in patients with osteoarthritis.

Tramadol HCl BP/EP Absorption

Racemic tramadol is rapidly and almost completely absorbed after oral administration. The mean absolute bioavailability of a 100 mg oral dose is approximately 75%.The mean peak plasma concentration of racemic tramadol and M1 occurs at two and three hours, respectively, after administration in healthy adults.

Tramadol HCl BP/EP side effects and Toxicity

LD₅₀=350mg/kg (orally in mice)

Tramadol HCl BP/EP Patient Information

No information avaliable

Tramadol HCl BP/EP Organisms Affected

Humans and other mammals